The Entourage Effect – What Is It?

Chances are that if you’ve done any research into Cannabis related products, such as CBD, you’ve heard of the Entourage Effect.

But what is it exactly? Do only certain types of Cannabis have it? Does CBD oil have it? More importantly… is it real?

Before you understand the ‘entourage effect’ you need to know that are over 400 trace compounds in Cannabis. This includes cannabinoids, like THC and CBD, terpenes, and flavonoids.

The Cannabinoids and Terpenes all have different biochemical effects on the body.

The Entourage Effect

The “Entourage Effect” is the theory that the combination of the individual compounds in cannabis has a synergistic effect, and they work better when in the presence of each other.

Did you notice we said theory?

CBD and THC, cannabidiol and tetrahydrocannabinol, are really the only two compounds that have been researched the most, but even these two haven’t been studied much.

Right now, for the most part all of the evidence to support the entourage effect is anedoctal, not clinical. With cannabis being such a complex plant it will take a lot of research to find out which compounds, if any, are important to be used together.

What the Research Does Say

The Entourage Effect theory was developed by a group of scientists in 1998, then popularized in a paper by Dr. Ethan Russo in 2011. This study found that taking the full combination of terepenes and cannabinoids might help with a wide variety of conditions including:

  • Pain
  • Inflammation
  • Sleep problems
  • anxiety

The problem with this is that no further research has actually proven this. This has not stopped many from concluding it is true and popularizing the theory.

At Plant Driven Health, we do believe in the ‘entourage effect’, to an extent. From the research we’ve done, we think the specific combination of cannabinoids and terpenes plays a very big role in their effectiveness.

This is because not only are there around 100 different terpenes in cannabis, but they vary greatly in the effect they have on the body. Click on the link in top right for our full video on Terpenes if you want to know more!

Because of the differences in terpenes in different strains of cannabis and CBD, one strain of cannabis might be great for treating pain, while another might be perfect as a sleep aid. But use the sleep aid strain for pain and the results might be less impressive.

This brings us to how we believe the Entourage Effect will play a huge part in the future of medicinal cannabis.  

We think in the future strains of cannabis will be developed with better and better ratios of cannabinoids and terpenes for different health conditions.

This makes the future of cannabis, and CBD oil and CBD based products, pretty exciting!

Dosing CBD Oil

Dosing CBD products is a fairly complicated topic. There are no FDA regulations or recommendations. Combine this with the fact that so little research has been done into dosing and you have uncertainty.

We have a full guide on dosing CBD oil, but here is a brief overview.

Start with .2 to 1mg of CBD per 10lbs of bodyweight. For a 200lbs man this means they would want to use 4 to 20mg of CBD to start.

This might be confusing, since many studies we talk about have used much higher dosages, but to be safe this is what we recommend to start with!

Final Thoughts on The Entourage Effect

While there really isn’t enough evidence to prove the entourage effect, we at Plant Driven Health do believe there is some validity to it!

As more research is published we will update this article to stay current!