The body is great at adapting to new stimuli and substances that we start to take. Therefore, to build muscle you have to lift heavier weights, or a coffee drinking needing more and more caffeine to get their desired boost. Does CBD fall into this category? Do you build a tolerance to CBD Oil?
Not all chemicals and substances cause our body to adapt though. There are things that we never adapt or build a tolerance too.
What causes our bodies to adapt, and will that happen as we take CBD?
How Does Tolerance Work?
Tolerance is something that is very individualized due to our unique genetic structure. Not only are some people more sensitive to substances in general, but people adapt to a new substance at different rates.
Even as we are talking about the categories of tolerance, realize that they vary from person to person.
The three broad categories that tolerance is defined by are cellular, metabolic, and behavioral. Most substances activate two, or all three of the categories to different extents.
With cellular tolerance, the body becomes less responsive to a substance. Metabolic tolerances occur when the body starts to block or limit the amount of a chemical reaching a targeted area. Finally, behavioral tolerance happens in the brain when we become psychologically adjusted to the effects of a substance.
Do You Build a Tolerance to CBD?
Anyone who has used cannabis medicinally or recreationally probably believes that you will build up a tolerance to CBD. Afterall, cannabis users build a tolerance and CBD is a component of the plant.
You will not build a tolerance to CBD. In fact, CBD benefits from a process referred to as reverse tolerance. THC, another common cannabinoid in cannabis, does build a tolerance in the body. The difference is how the two compounds bind with the endocannabinoid system.
When THC enters the body, it binds with CB1 receptors in the endocannabinoid system. After a while, the body builds a cellular tolerance to that binding process. This means there are less free CB1 receptors, and more THC is needed to feel the same effects.
Unlike THC that binds and limits receptor activity, CBD actually promotes increased receptor activity! This means you won’t build up a tolerance to CBD at all. In fact, CBD benefits from a concept known as reverse tolerance.
What is Reverse Tolerance?
This is a process also known as drug sensitization. When this occurs less of the substance causing the change in needed to get the same results! This in normally a fairly slow process, but in time you need less and less of the product.
It is believed that CBD works in a reverse tolerance model thanks to the increased receptor sensitivity that occurs. CBD also seems to help turn off receptors that are active that don’t need to be.
This means that over time receptors that need to be on will be on, and those that don’t will be resting, thus less CBD will be needed to get them to their desired state.
We’ve linked to a study that was published in 2015 on the topic that we found. As more research is available, we will add it to this section!
Final Thought on Building a Tolerance to CBD
The evidence definitely shows that you do not build a tolerance to CBD like you would cannabis, or more specifically THC and what little research that is available backs this up.
If you’re ready to get started with CBD, or looking for brands we use and believe in, check out our list of top CBD brands!